Erythropoietin receptors: their role beyond erythropoiesis
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چکیده
منابع مشابه
Erythropoietin receptors: their role beyond erythropoiesis.
It has been known for 40 years that erythropoietin, which is mainly produced by the kidney in response to hypoxia, is the primary regulator of red blood cell production and is indispensable for terminal differentiation of erythroid progenitors. It controls proliferation, maturation and also survival of erythroid progenitor cells. The binding of erythropoietin to its receptor, which exists as a ...
متن کاملBeyond Erythropoiesis: Emerging Metabolic Roles of Erythropoietin
Infiltration of inflammatory cells into adipose tissue causes insulin resistance in animal models and is associated with insulin resistance in humans (1,2). Among potential therapeutic approaches, the hormone erythropoietin (EPO) exerts anti-inflammatory effects in a variety of nonerythroid tissues (3), in which the receptor for EPO (EPO-R) is widely expressed (4). Various observations suggest ...
متن کاملBeyond erythropoiesis: the anti-inflammatory effects of erythropoietin.
Erythropoietin (EPO) is a 30.4-kDa glycoprotein essential for red blood cell production. In adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and stimulates erythroid progenitors in the bonemarrow to increase red blood cell mass. In addition to its role in erythropoiesis, EPO has been shown to protect against ischemic injury in several organs including the heart. I...
متن کاملErythropoietin and Erythropoiesis in
T hat androgenic hormones stimulate erythropoiesis in animals and man has been known for many years.1’2 The principle mechanism for this activity probably results from an increased production of erythropoietin since both serum and urine levels are elevated by androgens.35 Even when plasma erythropoietin content is high, as in most anemias, further enhancement may occur after administration of t...
متن کاملErythropoietin, iron, and erythropoiesis.
Recent knowledge gained regarding the relationship between erythropoietin, iron, and erythropoiesis in patients with blood loss anemia, with or without recombinant human erythropoietin therapy, has implications for patient management. Under conditions of significant blood loss, erythropoietin therapy, or both, iron-restricted erythropoiesis is evident, even in the presence of storage iron and i...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2005
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfh800